Effect of medicinal folk plants from Ban-Ang-Ed official Community Forest Project (The Chaipattana Foundation) on Cytochrome P4502A6 enzyme

Abstract

The liver specific cytochrome P4502A6 (CYP 2A6) plays an important role in degrading of tobacco specific nicotine, and excreting nicotine through urine. Interestingly, genetic polymorphism and enzymatic activity of CYP2A6 associated with smoking behavior. In this study, the effect of herb extracts from Ban-Ang-Ed official community forest project on CYP2A6 enzymatic activity (in vitro) based on local intellectual suggestion for health treatment for local resident were investigated. The results significantly showed the effect of plant extracts on CYP2A6 activity (p-value < 0.05). In this study, the Rauvolfia sp (roots), the Tacca chantrieri  (roots),  the Aidia wallichiana (leaves) could activate CYP2A13 enzyme activity.     On the other hand, the Ageratum conyzoides (leaves), the Aidia wallichiana (roots), Mahug (leaves), and Laykanok (leaves) could inhibit CYP2A13 enzyme activity in vitro.