Medicinal Property, Secondary Metabolite and Biological Activity of Selected Galactogogues Thai Medicinal Plants
Abstract
Plants are the sources of the four basic needs; food, shelter, clothing and medicine. In terms of being a medicine, medicinal plants have long been used in history to treat diseases in every parts of the world. It is a folk wisdom that has passed from one generation to another in the communities. The medicinal properties of the medicinal plants are due to their productions of active secondary metabolites. Medicinal plant-derived galactogogue is a group of those medicinal plants that breastfeeding mother use in now a day in order to increase breast milk production. Some of these medicinal plant-derived galactogogues have received attention and extensively studies on their biological activities and secondary metabolites. In this article, botanical characteristics, plant medicinal properties based on traditional uses, secondary metabolites and biological activities of 5 galactogogue medicinal plants; Polyalthia evecta, Uvaria rufa, Celastrus paniculatus, Diospyros ehretioides and Ochna integerrima, have been reviewed according to their uses as ingredients in traditional recipes in hospital and their remarkable chemical constituents. This information is very useful in the utilization of this group of plants for medical purposes, health promotion or safety information which leading us to understand and use these local resources in the most-cost effective and sustainable ways. Keyword : secondary metabolite ; biological activity ; bioactive compound ; plant-derived galactogogue ; galactogogueReferences
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Thaipost. July 18, 2018. Retrieved July 16, 2562, from https://www.thaipost.net/ main/detail/13648 (in Thai)
Tudla, F.A., Aguinaldo, A.M., Krohn, K., Hussain, H., & Macabeo, A.P.G. (2007). Highly oxygenated cyclohexene metabolites from Uvaria rufa. Biochemical Systematics and Ecology, 35, 45-47.
Weng, J.-R., & Yen, M.-H. (2010). New dihydroagarofuranoid sesquiterpenes from Celastrus paniculatu. Helvetica Chemica Acta, 93(9), 1716-1724.
Weng, J.-R., Yen, M.-H., & Lin, W.-Y. (2013). Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells. Phytochemistry, 94, 211-219.
Yimyam S. (2019). Medicinal plant-derived galactogogues for breastfeeding mothers. Nursing Journal, 45(1), 133-145. (in Thai)
Zhang, C.-R., Yang, S.-P., Liao, S.-G., Wu, Y., & Yue, J.-M. (2006). Polyoxygenated cyclohexene derivatives from Uvaria rufa. Helvetica Chimica Acta, 89, 1408-1416.
Borbone, N., Borrelli, F., Montesano, D., Izzo, A. A., De Merino, S., Capasso, R., & Zollo, F. (2007). Identification of a new sesquiterpene poly ester from Celastrus paniculatus. Planta Medica, 73(8), 792-794.
Borrelli, F., Borbone, N., Capasso, R., Montesano, D., Izzo, A. A., De Marino, S., & Zollo, F. (2004).
New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus.” Planta Medica, 70(7), 652–656.
Buntuchai, G., Pavadhgul, P., Kittipichai, W., & Satheannoppakao, W. (2017). Traditional galactagogue foods and their connection to human milk volume in Thai breastfeeding mothers. Journal of Human Lactation, 33(3), 552-559.
Concise encyclopedia of plants in Thailand. Retrieved April 14, 2020, from http://www.dnp.go.th/botany/detail_group.aspx?groupchar=%E0%B8%81 (in Thai)
Dailynews. August 12, 2018. Retrieved July 16, 2562, from https://www.dailynews.co.th/ politics/660137
(in Thai)
Deepralard, K., Kawanishi, K., Moriyasu, M., Pengsuparp, T., & Suttisri, R. (2009). Flavonoid glycosides rom the leaves of Uvaria rufa with advance glycation end-products inhibitory activity. Thai Journal of Pharmaceutical Science, 33, 84-90.
Homhuan S. (2010). Medicinal plant database, Faculty of Pharmacy, Ubon Ratchathani University. Retrieved July 24, 2019, from http://www.phargarden.com/main.php (in Thai)
Ichino, C., Kiyohara, H., Soonthornchareonnon, N., Chuakul , W., Ishiyama, A., Sekiguchi, H., Namatame, M., Otoguro, K., Omura, S., & Yamada, H. (2006). Antimalarial activity of bioflavonoids from Ochna integerrima. Planta Medica, 72(7), 611-614.
Kaewamatawong, R., Likhitwitayawuid, K., Ruangrungsi, N., Takayama, H., Kitajima, M., & Aimi, N. (2002). Novel bioflavonoids from the stem bark of Ochna integerrima. Journal of Natural Products, 65(7), 1027-1029.
Kanokmedhakul, S., Kanokmedhakul, K., Kantikeaw, I., & Phonkerd, N. (2006). 2-Substituted furans from the roots of Polyalthia evecta. Journal of Natural Products, 69, 68-72.
Likhitwitayawuid, K., Rungserichai, R., Ruangrungsi, N., & Phadungcharoen, T. (2001). Flavonoids from Ochna integerrima. Phytochemistry, 56(4), 353-357.
Loungnateetep, R. (1997). Spices and herbs. Bangkok: Odeon Store. (in Thai)
Luecha, P., & Umehara, K. (2013). Thai medicinal plant for promoting lactation in breastfeeding women. Handbook of dietary and nutritional aspects of human breast milk. Wageningen Academic Publishers, pp. 645-654.
Macabeo, A.P.G., Tudla, F.A., Alejandro, G.J.D., Kouam, S.F., Hussain, Hidayat., Krohn, K. 2010. Benzoylated derivatives from Uvaria rufa. Biochem Syst Ecol, 38(4), 857-860.
Macabeo, A.P.G., Tudla, F.A., Krohn, K., & Franzblau, S.G. (2012). Antitubercular activity of the semi-polar extractives of Uvaria rufa. Asian Pacific Journal of Tropical Medicine, 777-780.
Medthai. Retrieved July 24, 2019, from https://medthai.com/ (in Thai)
Mortel, M., & Mehta, S. D. (2013). Systematic review of the efficacy of herbal galactogogues. Journal of Human Lactation, 29(2), 154-162.
Nguyen, T.H., Ho, V.D., Do, T.T., Bui, H.T., Phan, V.K., Sak, K., & Raal, A. (2014). Natural Product Research, 29(3), 247-252.
Prajoubklang, A., Sirithunyalug, B., Charoenchai, P., Suvannakad, R., Sriubolmas, N., Piyamongkol, S., Kongsaeree, P., & Kittakoop, P. (2005). Bioactive deoxypreussomerins and dimeric naphthoquinones from Diospyros ehretioides fruits: Deoxypreussomerins may not be plant metabolites but may be from fungal epiphytes or endophytes. Chemistry & Biodiversity, 2(10), 1358-1367.
Reutrakul, V., Ningnuek, N., Pohmakotr, M., Yoosook, C., Napaswad, C., Kasisit, J., Santisuk, T., & Tuchinda, P. (2007). Anti HIV-1 flavonoid glycosides from Ochna integerrima. Planta Medica, 73(7), 683-688.
Rosandy, A.R., Din, L.B., Yaacob, W.A., Yusoff, N.I., Sahidin, I., Latip, J., Nataqain, S., & Noor, N.M. (2013). Isolation and characterization of compounds from the stem of Uvaria rufa (Annonaceae).
The Malaysian Journal of Analytical Sciences, 17(1), 50 -58.
Sasikumar, P., Sharanthna, P., Prabha, B., Varughese, S., Anil Kumar, N., Sivan, V. V., Sherin, D. R., Suresh, E., Manojkumar, T. K., & Radhakrishnan, K. V. (2018). Dihydro--agarofuran sesquiterpenoids from the seed of Celastrus paniculatus Willd. and their -glucosidase activity. Phytochemistry Letter, 26, 1-8.
Siamrath online. January 17, 2019. Retrieved July 16, 2562, from https://siamrath.co.th/n/61528 (in Thai)
Singh, G. (2010). Plant systematics an integrated approach. (3rd ed.). India: Science Publishers.
Thaipost. July 18, 2018. Retrieved July 16, 2562, from https://www.thaipost.net/ main/detail/13648 (in Thai)
Tudla, F.A., Aguinaldo, A.M., Krohn, K., Hussain, H., & Macabeo, A.P.G. (2007). Highly oxygenated cyclohexene metabolites from Uvaria rufa. Biochemical Systematics and Ecology, 35, 45-47.
Weng, J.-R., & Yen, M.-H. (2010). New dihydroagarofuranoid sesquiterpenes from Celastrus paniculatu. Helvetica Chemica Acta, 93(9), 1716-1724.
Weng, J.-R., Yen, M.-H., & Lin, W.-Y. (2013). Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells. Phytochemistry, 94, 211-219.
Yimyam S. (2019). Medicinal plant-derived galactogogues for breastfeeding mothers. Nursing Journal, 45(1), 133-145. (in Thai)
Zhang, C.-R., Yang, S.-P., Liao, S.-G., Wu, Y., & Yue, J.-M. (2006). Polyoxygenated cyclohexene derivatives from Uvaria rufa. Helvetica Chimica Acta, 89, 1408-1416.
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Published
2020-09-01
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