Development of Polymeric Hydrogels for Potential Biomedical Applications: Sol-Gel Synthesis and in Vitro Release of Mangiferin
Abstract
Polymeric hydrogels based on blending of polyvinyl alcohol, chitosan and gelatin were prepared and loaded with mangiferin, a naturally occurring glucosyl xanthone extracted from leaves of the mango tree. The structure of this bioactive compound was confirmed by FT-IR and NMR and its anti-microbial property was tested by the clear zone method. The developed binary, ternary and hybrid ternary blend hydrogels were characterized by FT-IR and SEM-EDX. The effects of polymer composition and siloxane hybrid network on the swelling behavior and in vitro release of mangiferin were investigated in aqueous media of pH 5.5 and 10.0. It was found that the hybrid hydrogel systems produced in this study seem promising as potential materials for biomedical applications. Keywords : polyvinyl alcohol, chitosan, hybrid, mangiferin, hydrogelReferences
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Bhowmik, D., Gopinath, H., Kumar, B.P., Duraivel, & S., Kumar, S.K.P. (2012). Controlled release drug delivery systems. The Pharma Innovation, 1(10), 24-32.
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Garnica-Palafox, I.M. & Sanchez-Arevalo F.M. (2016). Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels, Carbohydrate Polymers, 151, 1073-1081.
Ghaderi, J., Hosseini, S.F., Keyvani, N., & Gómez-Guillén, M.C. (2019). Polymer blending effects on the physicochemical and structural features of the chitosan/poly(vinyl alcohol)/fish gelatin ternary biodegradable films, Food Hydrocolloids, 95, 122-132.
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Neelakandan, C. & Kyu, T. (2009). Hydrogen bonding interactions and miscibility studies of poly(amide)/poly(vinyl pyrrolidone) blends containing mangiferin. Polymer, 50, 2885-2892.
Neto, R.J.G., Genevro, G.M., Paulo, L.A., Lopes, P.S., & Moraes, M.A., Beppu, M.M. (2019). Characterization and in vitro evaluation of chitosan/konjac glucomannan bilayer film as a wound dressing, Carbohydrate Polyners, 212, 59-66.
Ono, S., Imai, R., Ida, Y., Shibata, D., Komiya, T., & Matsumura, H. (2015). Increased wound pH as an indicator of local wound infection in second degree burns, Burns, 41, 820-824.
Pipattanawarothai, A., Suksai, C., Srisook, K., & Trakulsujaritchok, T. (2017). Non-cytotoxic hybrid bioscaffolds of chitosan-silica: Sol-gel synthesis, characterization and proposed application, Carbohydrate Polymers, 178, 190–199.
Pulat, M., & Ugurlu, N. (2016). Preparation and characterization of biodegradable gelatin-PAAm-based IPN hydrogels for controlled release of maleic acid to improve the solubility of phosphate fertilizers. Soft Materials, 14(4), 217-227.
Stoilova, I., Gargova, S., Stoyanova, A., & Ho, L. (2005). Antimicrobial and antioxidant activity of the polyphenol mangiferin. Herba Polonica, 51, 37-43.
Yanga, W., Owczarek, J.S., Fortunati, E., Kozanecki, M., Mazzagliac, A., Balestrac, G.M., Kennya, J.M., Torrea, L., & Puglia D. (2016). Antioxidant and antibacterial lignin nanoparticles in polyvinyl alcohol/chitosan films for active packaging. Industrial Crops and Products, 94, 800–811.
Yoosook, C., Bunyapraphatsara, N., Boonyakiat, Y., & Kantasuk, C. (2000). Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine, 6, 411-419.
Yuvaraja, G., Pathak, J.L., Weijiang, Z., Yaping, Z., & Xu. J. (2017). Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). International Journal of Biological Macromolecules, 103, 234–241.
Barreto, J.C., Trevisan, M.T.S., Hull, W.E., Erben, G., de Brito, E.S., Pfundstein, Wurtele, G., Spiegelhalder, B., & Owen, R.W. (2008). Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agricultural and Food Chemistry, 56, 5599-5610.
Bhowmik, D., Gopinath, H., Kumar, B.P., Duraivel, & S., Kumar, S.K.P. (2012). Controlled release drug delivery systems. The Pharma Innovation, 1(10), 24-32.
Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., & Ali, M. (2005). Analgesic and antioxidant activity of mangiferin and its derivatives: The structure activity relationship. BPB: Biological and Pharmaceutical Bulletin, 28, 596-600.
de Souza, J.R.R., de Carvalho, J.I.X., Trevisan, M.T.S., de Paula, R.C.M., Ricardo, N.M.P.S., & Feitosa, J.P.A. (2009). Chitosan-coated pectin beads: Characterization and in vitro release of mangiferin. Food Hydrocolloids, 23, 2278-2286.
de Souza, J.R.R., Feitosa, J.P.A., Ricardo, N.M.P.S., Trevisan, M.T.S., de Paula, H.C.B., Ulrich, C.M., & Owen, R.W. (2013). Spray-drying encapsulation of mangiferin using natural polymers. Food Hydrocolloids, 33, 10-18.
Garnica-Palafox, I.M. & Sanchez-Arevalo F.M. (2016). Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels, Carbohydrate Polymers, 151, 1073-1081.
Ghaderi, J., Hosseini, S.F., Keyvani, N., & Gómez-Guillén, M.C. (2019). Polymer blending effects on the physicochemical and structural features of the chitosan/poly(vinyl alcohol)/fish gelatin ternary biodegradable films, Food Hydrocolloids, 95, 122-132.
Guha, S., Ghosal, S., & Chattopadhyay, U. (1996). Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy, 42, 443-451.
Hu, D., Qiang, T., & Wang, L. (2017). Quaternized chitosan/polyvinyl alcohol/sodium carboxymethylcellulose blend film for potential wound dressing application. Wound Medicine, 16, 15–21.
Majd, S.A., Khorasgani, M.R., Moshtaghian, S.J., Talebi, A., & Khezri, M. (2016). Application of chitosan/PVA nanofiber as a potential wound dressing for streptozotocin-induced diabetic rats. International Journal of Biological Macromolecules, 92, 1162–1168.
Neelakandan, C. & Kyu, T. (2009). Hydrogen bonding interactions and miscibility studies of poly(amide)/poly(vinyl pyrrolidone) blends containing mangiferin. Polymer, 50, 2885-2892.
Neto, R.J.G., Genevro, G.M., Paulo, L.A., Lopes, P.S., & Moraes, M.A., Beppu, M.M. (2019). Characterization and in vitro evaluation of chitosan/konjac glucomannan bilayer film as a wound dressing, Carbohydrate Polyners, 212, 59-66.
Ono, S., Imai, R., Ida, Y., Shibata, D., Komiya, T., & Matsumura, H. (2015). Increased wound pH as an indicator of local wound infection in second degree burns, Burns, 41, 820-824.
Pipattanawarothai, A., Suksai, C., Srisook, K., & Trakulsujaritchok, T. (2017). Non-cytotoxic hybrid bioscaffolds of chitosan-silica: Sol-gel synthesis, characterization and proposed application, Carbohydrate Polymers, 178, 190–199.
Pulat, M., & Ugurlu, N. (2016). Preparation and characterization of biodegradable gelatin-PAAm-based IPN hydrogels for controlled release of maleic acid to improve the solubility of phosphate fertilizers. Soft Materials, 14(4), 217-227.
Stoilova, I., Gargova, S., Stoyanova, A., & Ho, L. (2005). Antimicrobial and antioxidant activity of the polyphenol mangiferin. Herba Polonica, 51, 37-43.
Yanga, W., Owczarek, J.S., Fortunati, E., Kozanecki, M., Mazzagliac, A., Balestrac, G.M., Kennya, J.M., Torrea, L., & Puglia D. (2016). Antioxidant and antibacterial lignin nanoparticles in polyvinyl alcohol/chitosan films for active packaging. Industrial Crops and Products, 94, 800–811.
Yoosook, C., Bunyapraphatsara, N., Boonyakiat, Y., & Kantasuk, C. (2000). Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine, 6, 411-419.
Yuvaraja, G., Pathak, J.L., Weijiang, Z., Yaping, Z., & Xu. J. (2017). Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). International Journal of Biological Macromolecules, 103, 234–241.
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Published
2019-09-06
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