Mathematical Modeling the Effects of Vaccination on HBV Infection in Thailand

Authors

  • Pensiri Yosyingyong
  • Ratchada Viriyapong

Abstract

Hepatitis B virus (HBV) infection is a disease characterized by inflammation of the liver. There are two types of hepatitis B virus infection, acute hepatitis B and chronic hepatitis B. The chronic hepatitis B is the most significant factor leading to liver cancer and cirrhosis. There are approximately 350 million people infected with the HBV worldwide, and 75% of them are from Asia. In Thailand, there are approximately 3% of the populations who are infected by HBV. Nowadays, the number of people who are infected by HBV is decreased due to                the present of vaccination. However, the number of infected people is still at high level and could be further reduced. Therefore, in this research we study and explore further by constructing and analyzing mathematical models relating to vaccination in the form of SVIR models. Numerical analysis is performed to explore the effect of some particular parameters to the overall dynamics. The basic reproduction number is also calculated.               This is to find some approaches to control the epidemic or reduce number of patients with HBV in Thailand. Keywords : hepatitis B, vaccine, mathematical model, numerical analysis

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2017-08-08

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บทความวิจัยจากการประชุมวิชาการระดับชาติ"วิทยาศาสตร์วิจัย"ครั้งที่ 9