Kappa-Carrageenan/Sodium Alginate Based Core-Shell Hydrogels for pH Sensitive Drug Delivery Systems
Abstract
The κ-carrageenan/sodium alginate core-shell beads were prepared by 2-step ionic gelation method for drug delivery system. SEM micrographs confirmed the successful encapsulation of κ-carrageenan core with sodium alginate shell. The pH sensitive behavior of core-shell beads was evident in simulated gastrointestinal tract condition. Swelling of the beads increased when pH of the environment changed from acidic (pH 1.2) to alkaline (pH 7.4). The hydrogel beads were loaded with a model drug, methylene blue, and their release was studied. The release profiles were effected with different parameters in the preparation step, such as, crosslink density, thickness of shell and porosity of the core. It was observed that the encapsulation of κ-carrageenan with sodium alginate shell reduced the premature release of drug in the stomach mimicked condition and released the drug more specifically to the colon mimicked condition. The release mechanism was investigated and best fitted with Hixson-Crowell model. These results suggest that core-shell beads could be further developed as effective drug delivery system with pH sensitive drug release ability. Keywords : carrageenan, sodium alginate, drug delivery, core-shell hydrogelReferences
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Xu, w., Jin, W., Zhang, C., Li, Z., Lin, L., Huang, Q., Ye, S. and Li, B. (2014). Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme. Food Research International, 59, 61-66.
Yue, Y., Han, J., Han, G., French, A.D., Qi, Y. and Wu, Q. (2016). Cellulose nanofibers reinforced sodium alginate- polyvinyl alcohol hydrogels: Core-shell structure formation and property characterization. Carbohydrate Polymers, 147, 155-164.
Zare-Akbari, Z., Farhadnejad, H., Furughi-Nia, B., Abedin, S., Yadollahi, M. and Khorsand-Ghayeni M. (2016). pH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier. International Journal of Biological Macromolecules, 93, 1317-1327.
Zeitoun, A. A., Dib, J.G. & Mroueh, M. (2003). A comparative single-dose bioequivalence study of two enteric coated aspirin brands among healthy volunteers. The Journal of Applied Research, 3(3), 242-248.
Hixson, A.W. and Crowell, J.H. (1931). Dependence of reaction velocity upon surface and agitation. Industrial and Engineering Chemistry, 23, 923-930.
Korsmeyer, R.W., Gurny, R., Doelker, E., Buri, P. and Peppas, N.A. (1983). Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics, 15, 25-35.
Kulkarni, R.V., Baraskar, V.V., Setty, C.M. and Sa, B. (2011). Interpenetrating polymer network matrices of sodium alginate and carrageenan for controlled drug delivery application. Fibers and Polymers, 12, 352-358.
Lin, N., Geze, A., Wouessidjewe, D., Huang, J. and Dufresne, A. (2016). Biocompatible double-membrane hydrogels from cationic cellulose nanocrystals and anionic alginate as complexing drugs codelivery. ACS Applied Materials & Interfaces, 8, 6880-6889.
Navikaite, V., Simanaviciute, D., Klimaviciute, R., Jakstas, V. and Ivanauskas, L. (2016). Interaction between κ- and ι-carrageenan and anthocyanins from Vaccinium myrtillus, Carbohydrate Polymers, 148,
36-44.
Wu, J., Kong, T., Yeung, K., Ho, C.S., Cheung, K., Wang, L. and To, M. (2013). Fabrication and characterization of monodisperse PLGA–alginate core–shell microspheres with monodisperse size and homogeneous shells for controlled drug release. Acta Biomaterialia, 9, 7410-7419.
Xu, w., Jin, W., Zhang, C., Li, Z., Lin, L., Huang, Q., Ye, S. and Li, B. (2014). Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme. Food Research International, 59, 61-66.
Yue, Y., Han, J., Han, G., French, A.D., Qi, Y. and Wu, Q. (2016). Cellulose nanofibers reinforced sodium alginate- polyvinyl alcohol hydrogels: Core-shell structure formation and property characterization. Carbohydrate Polymers, 147, 155-164.
Zare-Akbari, Z., Farhadnejad, H., Furughi-Nia, B., Abedin, S., Yadollahi, M. and Khorsand-Ghayeni M. (2016). pH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier. International Journal of Biological Macromolecules, 93, 1317-1327.
Zeitoun, A. A., Dib, J.G. & Mroueh, M. (2003). A comparative single-dose bioequivalence study of two enteric coated aspirin brands among healthy volunteers. The Journal of Applied Research, 3(3), 242-248.
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2017-07-26
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บทความวิจัยจากการประชุมวิชาการระดับชาติ"วิทยาศาสตร์วิจัย"ครั้งที่ 9
