Inhibition of Pig (Sus domesticus) Brain Monoamine Oxidase Enzymes by Some Thai Herbal Extracts
Abstract
Nowadays, the number of neurological disease patients, such as depression, attention deficit disorder, and Parkinson's disease has been increasing. Monoamine oxidase (MAO) enzyme, both isforms; MAO-A and MAO-B, have been reported as important therapeutic targets of these neurological diseases. Excess MAO mediates serotonin and dopamine metabolism leading to decreased levels of these neurotransmitters. In addition, lipid-peroxidation by the metabolic product of this neurotransmitter metabolism, the hydrogen peroxide (H2O2), was proposed as another factor that could facilitate the progression of degenerative brain tissue in patients. This study aims to develop an ABTS assay method to screen the extracts from Thai herbal that can inhibit MAO activity presence in pig (Sus domesticus) brain lysate. The results showed that the pig brain homogenate can metabolized p-tyramine substrate and the extracts from Rheum palmatum L. can inhibited pig brain MAO-B with an IC50 value of 18.26 µg/ml, while those of Vernonia cenerea can inhibited pig brain MAO-A with an IC50value of 3.53 µg/ml. Keywords: monoamine oxidase, monoamine oxidase A, monoamine oxidase B, inhibition, Thai herbal extractReferences
Abell, C.W., Kwan, S.W. (2001). Molecular characterization of mono amine oxidase A and B. Progress in Nucleic Acid Research and Molecular Biology, 6, 129-156.
Bai, C., Meng, H., Zhao, W., Pan, Y. (2005). Molecular cloning and characterization of monoamine oxidase A and B genes in pig. DNA Sequencing, 16(3), 161-165.
Brown, C.S., Kent, T.A., Bryant, S.G., Gevedon, R.M., Campbell, J.L., Felthous, A.R., Barratt, E.S., Rose, R.M. (1989). Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research, 27, 5–12.
Butterweck, V., Nahrstedt, A., Evans, J., Hufeisen, S., Rauser, L., Savage, J., Popadak, B., Ernsberger, P., Roth BL. (2002). In vitro receptor screening of pure constituents of St. John's Wort reveals novel interactions with a number of GPCRs. Psychopharmacology Bulletin, 162, 193–202.
Chung, J.Y., Lee, J.W., Ryu, C.H., Min, H.K., Yoon, Y.J., Lim, M.J., Park, C.H. (2015). 1-[2-(4-Benzyloxyphenoxy) Ethyl] Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease. Journal of Neuroscience Research, 93, 1267-1278.
Davison, A.N. (1958). Physiological Role of Monoamine Oxidase. Physiological Review, 38, 729-747.
Finberg, J.P.M, Gillman, P.K. (2011). Selective inhibitors of monoamine oxidase Type B and the “cheese effect”.In YoudimMB, Riederer P.(Eds.) International Review of Neurobiology, 100, 169–190.
Finberg, J.P.M. (2014). Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release. Pharmacology & Therapeutics, 143,
133-152.
Fišar, Z., Hroudová, J., Raboch, J. (2010). Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers. Neuroendocrinology Letters, 31(5), 645–656.
Haraguchi, H., Tanaka, Y., Kabbash, A., Fujioka, T., Ishizu, T., Yagi A. (2004). Monoamine oxidase inhibitors from Gentiana lutea. Phytochemistry, 65, 2255-2260.
Herraiz, T., González, D., Ancín-Azpilicueta, C., Arán, V.J., Guillén, H. (2010). ß-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48, 839-845.
Hou, W.C., Lin, R.D., Chen, C.T., Lee, M.H. (2005). Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. Journal of Ethnopharmacology, 100, 216–220.
Huong, D.T.L., Dat, N.T., Minh, C.V., Kang, J.S., Kim, Y.H. (2002). Monoamine oxidase inhibitors from Aquilaria agallocha. Natural Product Sciences, 8, 30–33.
Iwalewa, E.O., Iwalewa, O.J., Adeboye, J.O. (2003). Analgesic, pyretic,anti-inflammatory effects of methanol, choloform and ether extract of Vernonia cinerea less leaf. Journal of Ethnopharmacology, 86,
229-34.
Jager, A.K., Gauguin, B., Andersen, J., Adsersen, A., Gudiksen, L. (2013). Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A. Journal of Ethnopharmacology, 145, 822–825.
Jeffrey, B., Harborne, F.R. (1999). Photochemical dictionary, 2nd ed.UK. Taylor&Francis Ltd.
Jo, Y.S., Houng, D.T.L., Bae, K., Lee, M.K., Kim, Y.H. (2002). Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium. Planta Medica, 68, 84–85.
Kong, L.D., Cheng, C.H.K., Tan, R.X. (2004). Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. Journal of Ethnopharmacology, 91(2-3), 351-5.
Lin, R.D., Hou, W.C., Yen, K.Y., Lee, M.H. (2003). Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines. Phytomedicine, 10, 650-656.
Mazzio, E., Deiab, S., Park, K., Soilman, K.F.A. (2013). High throughput screening to identify natural human monoamone oxidase B inhibitors. Phytotherapy Research, 27(6), 818-828.
Riederer, P., Lachenmayer, L., Laux, G. (2004). Clinical applications of MAO-inhibitors. Current Medicinal Chemistry, 11, 2033-2043.
Saura, J., Luque, J.M., Cesura, A.M., Da, P.M., Chan-Palay, V, Huber, G. (1994). Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience, 62, 15–30.
Stafford, G.I., Pedersen, P.D., Jager, A.K., Staden, J. (2007). Monoamine oxidase inhibition by southern African traditional medicinal plants. South African Journal of Botany, 73, 384-390.
Tao, G., Irie, Y., Li, D.J., Keung, W.M. (2005). Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorganic and Medicinal Chemistry, 13, 4777–4788.
Tipton, K.F. (1968a). The reaction pathway of pig brain mitochondrial monoamine oxidase. European Journal of Biochemistry. 5, 316-320.
Tipton K.F. (1968b). The purification of pig brain mitochondrial monoamine oxidase. European Journal Biochemistry. 4, 103-107.
World He
Bai, C., Meng, H., Zhao, W., Pan, Y. (2005). Molecular cloning and characterization of monoamine oxidase A and B genes in pig. DNA Sequencing, 16(3), 161-165.
Brown, C.S., Kent, T.A., Bryant, S.G., Gevedon, R.M., Campbell, J.L., Felthous, A.R., Barratt, E.S., Rose, R.M. (1989). Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research, 27, 5–12.
Butterweck, V., Nahrstedt, A., Evans, J., Hufeisen, S., Rauser, L., Savage, J., Popadak, B., Ernsberger, P., Roth BL. (2002). In vitro receptor screening of pure constituents of St. John's Wort reveals novel interactions with a number of GPCRs. Psychopharmacology Bulletin, 162, 193–202.
Chung, J.Y., Lee, J.W., Ryu, C.H., Min, H.K., Yoon, Y.J., Lim, M.J., Park, C.H. (2015). 1-[2-(4-Benzyloxyphenoxy) Ethyl] Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease. Journal of Neuroscience Research, 93, 1267-1278.
Davison, A.N. (1958). Physiological Role of Monoamine Oxidase. Physiological Review, 38, 729-747.
Finberg, J.P.M, Gillman, P.K. (2011). Selective inhibitors of monoamine oxidase Type B and the “cheese effect”.In YoudimMB, Riederer P.(Eds.) International Review of Neurobiology, 100, 169–190.
Finberg, J.P.M. (2014). Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release. Pharmacology & Therapeutics, 143,
133-152.
Fišar, Z., Hroudová, J., Raboch, J. (2010). Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers. Neuroendocrinology Letters, 31(5), 645–656.
Haraguchi, H., Tanaka, Y., Kabbash, A., Fujioka, T., Ishizu, T., Yagi A. (2004). Monoamine oxidase inhibitors from Gentiana lutea. Phytochemistry, 65, 2255-2260.
Herraiz, T., González, D., Ancín-Azpilicueta, C., Arán, V.J., Guillén, H. (2010). ß-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and Chemical Toxicology, 48, 839-845.
Hou, W.C., Lin, R.D., Chen, C.T., Lee, M.H. (2005). Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. Journal of Ethnopharmacology, 100, 216–220.
Huong, D.T.L., Dat, N.T., Minh, C.V., Kang, J.S., Kim, Y.H. (2002). Monoamine oxidase inhibitors from Aquilaria agallocha. Natural Product Sciences, 8, 30–33.
Iwalewa, E.O., Iwalewa, O.J., Adeboye, J.O. (2003). Analgesic, pyretic,anti-inflammatory effects of methanol, choloform and ether extract of Vernonia cinerea less leaf. Journal of Ethnopharmacology, 86,
229-34.
Jager, A.K., Gauguin, B., Andersen, J., Adsersen, A., Gudiksen, L. (2013). Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A. Journal of Ethnopharmacology, 145, 822–825.
Jeffrey, B., Harborne, F.R. (1999). Photochemical dictionary, 2nd ed.UK. Taylor&Francis Ltd.
Jo, Y.S., Houng, D.T.L., Bae, K., Lee, M.K., Kim, Y.H. (2002). Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium. Planta Medica, 68, 84–85.
Kong, L.D., Cheng, C.H.K., Tan, R.X. (2004). Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. Journal of Ethnopharmacology, 91(2-3), 351-5.
Lin, R.D., Hou, W.C., Yen, K.Y., Lee, M.H. (2003). Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines. Phytomedicine, 10, 650-656.
Mazzio, E., Deiab, S., Park, K., Soilman, K.F.A. (2013). High throughput screening to identify natural human monoamone oxidase B inhibitors. Phytotherapy Research, 27(6), 818-828.
Riederer, P., Lachenmayer, L., Laux, G. (2004). Clinical applications of MAO-inhibitors. Current Medicinal Chemistry, 11, 2033-2043.
Saura, J., Luque, J.M., Cesura, A.M., Da, P.M., Chan-Palay, V, Huber, G. (1994). Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience, 62, 15–30.
Stafford, G.I., Pedersen, P.D., Jager, A.K., Staden, J. (2007). Monoamine oxidase inhibition by southern African traditional medicinal plants. South African Journal of Botany, 73, 384-390.
Tao, G., Irie, Y., Li, D.J., Keung, W.M. (2005). Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorganic and Medicinal Chemistry, 13, 4777–4788.
Tipton, K.F. (1968a). The reaction pathway of pig brain mitochondrial monoamine oxidase. European Journal of Biochemistry. 5, 316-320.
Tipton K.F. (1968b). The purification of pig brain mitochondrial monoamine oxidase. European Journal Biochemistry. 4, 103-107.
World He
Downloads
Published
2017-07-19
Issue
Section
บทความวิจัยจากการประชุมวิชาการระดับชาติ"วิทยาศาสตร์วิจัย"ครั้งที่ 9
